Challenges Associated with Implementation of Clinical Guidelines


1. Klasco RS, Glinert LH. Language for Actionable Recommendations in Clinical Guidelines: Avoiding Hedging and Equivocation. JAMA. 2017;317(6):583-584. doi:10.1001/jama.2016.20670
2. Greenfield S. Clinical Practice Guidelines: Expanded Use and Misuse. JAMA. 2017;317(6):594-595. doi:10.1001/jama.2016.19969

Medical Affairs professionals frequently discuss clinical practice guidelines with external stakeholders. These discussions may differ when meeting, for example, with a clinical investigator versus a payer.

A recent article (Viewpoint) in the February 14, 2017, issue of JAMA describes some discrepancy between “the nature of the guidance that physicians provide as individuals and the guidance provided by professional societies.”1Klasco and Glinert note that the guidance from professional societies sometimes appears equivocal rather than actionable, using such words as “should,” or “if feasible,” and they emphasize the need for clinically straightforward language to assist clinicians with their decision making.

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